A mod will likely intervien, but since your issue is most likely mod related, you should probably have posted this in the Game Tweaking section.
However, you should try running the game without any mods (just 1.02) and see if you still have the same problems. The high-res patch isn't very demanding.. Evne with it applied, your graphics card is doing far less work than with any other modern game. However, just outof curiosity, what ARE your system specs (processor, memory, hd, graphics card)?