the inital load is a bit slower, but i can't notice anything on my ancient rig.
Single-core 2800+ XP-M processor (2.3GHz)
2Gigs RAM
HD3850 AGP Gfx
i run the game at 1600x1200 (or whatever is close to that, im not at my computer now)
If it doesn't slow my computer down, i think you guys will be okay.
lee
*edit* the main resoultion for new textures is 512x512 or smaller, with only 1 texture weighing in at 1024x1024(it was 128x128 by default for some odd reason)