RTS with RPG elements.
You are a mutant c*ckroach queen, escaped from a biological research lab whose goal was to produce an organism which can survive on other planets and make them habitable for human life. Your goal is to accomplish the mission objectives (breed n workers, gather n resources, drive off humans, survive fumigation, move queen to n location (maybe to a spaceship, so you can colonize other planets), move n soldiers to x location, whatever), sometimes within a time limit.
You lay eggs, which can hatch into different kinds of roaches. Workers gather resources, tend the brood, and care for the queen and drones. Soldiers kill things. Scouts carry diseases to enemies (debuffs) and and retrieve/steal things. If you get the wings advancements, these roaches can fly. Larvae queens, for when your current queen dies (the larvae queens will remain larvae until the current queen dies or moves away from the colony for n clockticks). You need more queens because every roach has a limited lifespan (unless you find the immortality advancement) and gradually become less effective and require more food to keep going (they get old), unless you find the eternal youth advancement, which will allow your roaches to keep their starting (minimal) food requirements as long as they live, barring injury. If you run out of live queens and have no larvae (or if the only queen is out of range), then the option to lay a queen will appear on several of your workers the longer they live without a queen. This queen will have all the resistances of the worker that lays it.
Each egg laid requires a certain amount of carbohydrate, fat, protein, water, and trace minerals. You acquire these nutrients by eating things. Dead things (including roaches, eggs), food dropped on the floor and behind couches or whatever, food hidden in cabinets and refridgerators that you must infiltrate to acquire them, sleeping people and animals (only from roaches grown from eggs laid after you acquire the blood suck advancement), plants, wood, plastic (requires iron stomach advancement).
Each advancement requires n nutrients to acquire, and it only applies to eggs laid after you acquire the advancement.
Enemies include people, animals, other roaches, and environmental hazards. The first time you're exposed to each poison, it will kill all but a few of your roaches (the queen has better immunities, and it will only drain her health instead of outright kill her), the survivors being the ones who have a measure of resistance.
So yeah, an RTS/RPG where roaches fight ants on the floor of your apartment and then scatter and live of scraps when you turn the light on.