My best guess is that you're running another program, maybe in the background, which conflicts with it. You should be able to run it just fine.
I've been hoping someone would write a superior program to Meteor, something that can edit on the fly ala Loveless without having to decompress, edit, and compress again with the correct "ritual". It makes overhauling the game VERY, VERY annoying, slow, and it was my opinion that it wasn't worth it.