Ahaa I do enjoy beating on the useless guests....
also, if you get the Focus ability for Squires, it increases your physical attack by +1 (regrettably, all changes are reset after battle...) and the animation doesn't take very long.
once you have JP Boost (also Squire:- I strongly recommend getting this ability asap) then it makes things a bit faster.
with regards to missable items though... the only one I can think of is the Tynar Rouge, but that's quite late-game. Look on GameFAQs if you want to learn how to get it, I can't remember.
My advice though;
always have a healerThere is nothing more annoying than a character dying once you get them to the jobs you wanted
