Hrm, I've fiddled around a LOT with this kind of stuff with EPSXE, if you configure the plugin just right, then it should be okay. I tip for getting up the framerates, raise the framerate limit just a tad (say, 65 or 70 fps) and see if you get a speed boost. Also, don't try to put ALL of the super special options on, because most of the require fat amounts of ram (I have 512MB, so I don't have many problems). If you're running anything under 256 megs of ram, you are gonna have LOTS of problems, because these emulators require 256 megs and recommend 512 megs (although, if your computer is fast enough, you shouldn't have too many problems with 256 megs if you configure it correctly).
Also, try and use the hardware options as much as possible with your card, software options will only make it worse.